Homologous Skin Transplantation from F1 Hybrid Mice to Parent Strains.

Abstract

Summary 1) Using several “F₁ hybrid to parent” strain combinations homotransplantation of skin from F₁ hybrid mice onto members of both parent strains has been attempted. 2) Results showed that while most “F₁ to parent” homologous skin grafts were unsuccessful, skin taken from (Z x Ce) F₁ or (Ce x Z) F₁ grafted onto mice of Z parent strain 26 to 47 days of age, was successfully established in most cases. Moreover, older recipients of same strain, particularly those ranging from 83 to 119 days in age, rejected the F₁ skin in all instances. 3) Exchange of skin homografts between mice of Z and Ce strain was regularly unsuccessful regardless of recipient's age at time of grafting. 4) Acquired immunological tolerance to (Z x Ce) F₁ homologous skin grafts was achieved in weanling Z mice injected intravenously with viable spleen cells taken from adult F₁ donors.