Age-related decline of human interferon alpha and interferon gamma production
- 1 May 1984
- journal article
- research article
- Published by Springer Nature in Blut: Zeitschrift für die Gesamte Blutforschung
- Vol. 48 (5), 285-289
- https://doi.org/10.1007/bf00320399
Abstract
Summary The influence of donor age on the production of interferon (IFN) alpha and IFN gamma by human peripheral blood mononuclear cells in vitro has been studied. The results demonstrate an age-related decline of the capacity to synthesize and secrete antiviral activity. Yields of virus-induced IFN alpha and lectin-induced IFN gamma were significantly decreased in mononuclear cell cultures from older subjects (> 50 years) when compared to those of younger subjects (< 50 years). The observed deficiency of IFN production may be involved in the increased susceptibility of aged humans to viral infections and malignant diseases.Keywords
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