SIMPLE AND CHEMOSELECTIVE SYNTHESIS OF KETONES FROM CARBOXYLIC ACIDS AND GRIGNARD REAGENTS USING DICHLOROTRIPHENYLPHOSPHORANE
- 5 August 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 12 (8), 1267-1270
- https://doi.org/10.1246/cl.1983.1267
Abstract
Dichlorotriphenylphosphorane was found to be a good condensation reagent for synthesis of ketones from carboxylic acids and Grignard reagents under mild conditions. Synthetic utility of the present method is demonstrated by the chemoselective reaction of carboxylic acids possessing such a functional group as halogen, cyano, or carbonyl.Keywords
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