INDISPENSABILITY OF THE ADRENALS FOR THE NEPHROSCLEROTIC ACTION OF HYPOPHYSEAL PREPARATIONS1

Abstract

WHETHER the somatotrophic hormone (STH) exerts any adrenalmediated actions is still much debated. Many STH effects are certainly not dependent upon the integrity of the adrenals. For instance, somatotrophin can stimulate skeletal growth, proliferation of lymphatic tissues and inflammatory granuloma formation, even in adrenalectomized rats, provided the animals receive adequate maintenance therapy in the form of salt-supplements or corticoids. Yet, it has never been possible, either with purified STH preparations or with crude lyophilized anteriorpituitary (LAP) tissue, to produce nephrosclerosis in adrenalectomized rats.