NMR studies of the Na+, Mg2+ and Ca2+ complexes of cyclosporin A

1 January 1992

journal article
research article
Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications

No. 22,p. 1682-1684
https://doi.org/10.1039/c39920001682

Abstract

The immunosuppressant cyclosporin A has been shown by NMR spectroscopy to form complexes with Na⁺, Ca²⁺ and Mg²⁺ in acetonitrile; Ca²⁺ and Mg²⁺ form 1 : 1 complexes and the conformation of cyclosporin A changes dramatically upon binding of the metal ions.

Keywords

CONFORMATION
CA2
MG2
IMMUNOSUPPRESSANT
ACETONITRILE
DRAMATICALLY
NMR STUDIES
CYCLOSPORIN

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