Langerhans Cell Histiocytosis

Abstract

Nearly a century has passed since Alfred Hand reported a case of "polyuria and tuberculosis,"¹ later considered to be the first case of the Hand-Schül1er–Christian syndrome. Although early investigators considered this syndrome pathologically distinct from Letterer–Siwe disease, the later recognition of eosinophilic granuloma of bone as part of the same spectrum led Lichtenstein to propose the pathologically inclusive term "histiocytosis X" for the varying clinical manifestations.² Modern pathological techniques have revealed the identity of the offending cell, and we can now call this disorder by its proper name, Langerhans cell histiocytosis.³ The Langerhans cell is a dendritic cell derived from . . .