Cyclization of peptides on a solid support. Application to cyclic analogs of Substance P
- 1 February 1987
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 29 (2), 162-169
- https://doi.org/10.1111/j.1399-3011.1987.tb02242.x
Abstract
The general conditions for cyclization of peptides on polymer matrix by disulfide bridge formation are reported. This procedure is based on attack of 3-nitro-2-pyridinesulfenyl group (Npys) by a thiol function. It has been used for synthesis of five cyclic analogs of Substance P.Keywords
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