METABOLISM OF COENZYME Q IN CHICK EMBRYO

Abstract
Coenzyme Q was isolated in nearly pure form from hen''s-egg yolks. Coenzyme Q10 homologue was present and the average quantity/yolk was about 0[center dot]134 [mu]mole, in the batch of eggs tested. During the initial stages of development the coenzyme Q content of embryos increased while there was a simultaneous decrease in the yolk residue. [C14]Coenzyme Q injected into embryonated eggs was absorbed by the embryo at the 3 stages of development tested: 5th, 10th and 15th days. Both in vitro and in vivo [2-C14]mevalonic acid was incorporated into coenzyme Q by embryos at about the 10th day of development, but not on the 5th day. Sterol synthesis by chick embryos was demonstrated as early as the 4th day of development.