Effect of inosine on guinea-pig bronchial muscle

Abstract

Inosine, like other purine derivatives, shows antibronchospastic effects both in vivo and in vitro. Its activity remains in propranololor α-methyl-p-tyrosine-pretreated guinea-pigs, but is prevented by theophylline. Moreover, the interaction between 3′5AMP and inosine suggests potentiation. In view of recent findings showing that inosine inhibits phosphodiesterases, the conclusion is drawn that the antibronchospastic effect of this nucleoside depends on the increase of 3′5′AMP intracellular levels in the bronchial muscle.