The Influence of Transplanted Normal Tissue on Breast Cancer Ratios in Mice

Abstract

Earlier work on foster-nursing indicated that some influence was present in the milk of breast cancer strain oo which played a role in breast tumor etiology. Following the transplantation of grafts of spleen, thymus and mammary tissue from 4-5 wk. old donors of a high breast tumor strain into resistant and 1st and 2d generation hybrid mice, a significant increase in the breast tumor incidence was noted among the hybrid mice having the breast cancer susceptibility. Resistant or low breast tumor strain mice showed no increase. By the inoculation of normal tissues or organs from high cancer stock mice an influence may be transmitted which produces results similar to those of the "breast cancer producing influence" normally obtained in the milk while nursing.