The potential of nucleic acid repair in functional genomics
- 1 April 2001
- journal article
- review article
- Published by Springer Nature in Nature Biotechnology
- Vol. 19 (4), 321-326
- https://doi.org/10.1038/86701
Abstract
Chimeric RNA/DNA oligonucleotides have been used successfully to correct point and frameshift mutations in cells as well as in animal and plant models. This approach is one of several nucleic acid repair technologies that will help elucidate the function of newly discovered genes. Understanding the mechanisms by which these different technologies direct gene alteration is essential for progress in their application to functional genomics.Keywords
This publication has 43 references indexed in Scilit:
- The DNA strand of chimeric RNA/DNA oligonucleotides can direct gene repair/conversion activity in mammalian and plant cell-free extractsNucleic Acids Research, 2000
- Correction of chromosomal point mutations in human cells with bifunctional oligonucleotidesNature Biotechnology, 1999
- Targeted gene repairGene Therapy, 1999
- Mechanism and Utility of an RNA-Cleaving DNA EnzymeBiochemistry, 1998
- Ribozyme-Mediated Repair of Sickle β-Globin mRNAs in Erythrocyte PrecursorsScience, 1998
- Ribozyme-mediated trans-splicing of a trinucleotide repeatNature Genetics, 1998
- Repair of thalassemic human β-globin mRNA in mammalian cells by antisense oligonucleotidesProceedings of the National Academy of Sciences, 1996
- RibozymesCurrent Opinion in Biotechnology, 1992
- The excision of intervening sequences from salmonella 23S ribosomal RNACell, 1990
- Ribozymes and Their Medical ImplicationsPublished by American Medical Association (AMA) ,1988