Imipenem antagonism of the in vitro activity of piperacillin against Pseudomonas aeruginosa
- 1 August 1984
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 26 (2), 272-274
- https://doi.org/10.1128/aac.26.2.272
Abstract
The MICs of imipenem and piperacillin, alone and in combination, against Pseudomonas aeruginosa were determined in a checkerboard titration microdilution assay. A dramatic, one-way antagonism of imipenem for piperacillin was demonstrated in 28 of the 35 strains examined; antagonism was associated with the induction of a beta-lactamase.Keywords
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