Analysis of the Time Relationship for the Interaction of X-ray-induced Primary Breaks in the Formation of Dicentric Chromosomes
- 1 January 1976
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 30 (4), 339-346
- https://doi.org/10.1080/09553007614551111
Abstract
In split-dose experiments, the time relationship for the interaction of primary breaks in the formation of dicentric chromosomes was analyzed. Human peripheral lymphocytes were irradiated with a dose of 340 R of 220 kV X-rays split into 2 equal fractions separated by intervals up to 360 min. Assuming an exponential decline of the time-dependent quadratic component of the dose relation of dicentrics a theoretical formula was deduced. Fitting this formula to the empirical data a mean time of 110 min could be calculated in which primary breaks induced by both dose-fractions can interact to form dicentric chromosomes.This publication has 9 references indexed in Scilit:
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