VITAMIN A DEFICIENCY AND ISOPRENOID METABOLISM
- 1 May 1961
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology
- Vol. 39 (5), 855-861
- https://doi.org/10.1139/o61-085
Abstract
Vitamin A deficiency in the intact rat evokes an increase in liver ubiquinone and the incorporation of mevalonate into ubiquinone and squalene. This aberration is caused by a metabolic block between squalene and cholesterol. The addition of vitamin A in vitro to vitamin A deficient liver homogenates does not influence the metabolic defect. The vitamin A deficient guinea pig does not exhibit an increase in liver ubiquinone or incorporation of mevalonate into ubiquinone or squalene, but the incorporation into sterols is enhanced.Keywords
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