A CHEMICAL ANALYSIS OF THE PHOSPHOLIPIDS OF THE BRAIN IN DISSEMINATED SCLEROSIS

Abstract

A comparative analysis of non-affected and disseminated sclerosis brains showed that there is a severe depletion of phospholipids in both gray and white matter of the latter. At the same time, there is a marked increase in the P of the non-extractable residue, indicating an accumulation of P in the proliferated glia. The analysis of the brain from a patient with pellagra showed a similar distribution of phospholipids in the brain. In Alzheimer''s disease, arteriosclerosis and vascular syphilis, the P content was within normal limits, but the residue of extraction in arteriosclerosis and vascular syphilis showed an increase in P, which was interpreted to indicate a similar accumulation of P in the proliferated glia.