Oxime Esters as Acylating Agents in the Aminolysis Reaction. A Simple and Chemoselective Method for the Preparation of Amides from Amino Alcohols

Abstract

Oxime esters, such as acetone O-alkanoyl-, O-alkenoyl- or O-benzyloxycarbonyloximes, react with amines under extremely mild conditions to give the corresponding amides in very good yield. When amino alcohols are used a total chemoselectivity is observed.