Reduction of Rat Liver Carcinogenicity of α-Nitrosomorpholine by a-Deuterium Substitution 2
- 1 December 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 57 (6), 1311-1313
- https://doi.org/10.1093/jnci/57.6.1311
Abstract
Groups of 30 male Sprague-Dawley rats were given 4-nitrosomorpholine-3,3,5,5-d4 in their drinking water at concentrations of 0.35 and 0.07×10−3M for 30 weeks. Two similar groups of rats were simultaneously given unlabeled 4-nitrosomorpholine (NM) at the same molar concentrations; all animals were observed throughout their lives. Those receiving the α-deuteriumlabeled compound had significantly fewer liver tumors than did the corresponding animals receiving the unlabeled compound. The difference in potency appeared to be at least fivefold, a magnitude consistent with a primary kinetic isotope effect on the carcinogenic action of NM. Thus breakage of a bond linking a hydrogen (deuterium) atom with a carbon adjacent to the nitrosamino function may be involved in a rate-limiting step of carcinogenesis by NM.Keywords
This publication has 1 reference indexed in Scilit:
- Studies on the Carcinogenic Activity of Protein-Denaturing Agents: Hepatocarcinogenicity of Dioxane2JNCI Journal of the National Cancer Institute, 1965