The long-term effect of cisplatin on renal function
- 15 November 1986
- Vol. 58 (10), 2214-2217
- https://doi.org/10.1002/1097-0142(19861115)58:10<2214::aid-cncr2820581009>3.0.co;2-i
Abstract
The long-term effect of cisplatin on renal function was studied in a follow-up investigation, 16 to 52 months after chemotherapy in 22 patients with disseminated nonseminomatous testicular cancer. The median cumulated cisplatin dose was 452 mg/in2 (range, 275–650 mg/m2). Prehydration with isotonic saline secured diuresis above 100 ml/hour. GFR (glomerular filtration rate: 51Cr-EDTA clearance) fell by 12.5% (median, P < 0.01) compared with the pretreatment level. Effective renal plasma flow (125I-hippuran clearance) was estimated to be likewise reduced. The serum creatinine level rose 8 μmol/1 (median, P < 0.05) during the treatment period with no further rise afterwards. Serum magnesium and urinary excretion of beta-2-microglobulin were normal. The results indicate a moderate and permanent reduction in GFR with no signs of long-term tubular defects in patients treated with cisplatin.This publication has 14 references indexed in Scilit:
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