In 1914, Simmonds1reconstructed from necropsy studies of two cases the clinical syndrome which results from destruction of the anterior lobe of the hypophysis. Since that time a number of cases have been described in the German literature, although none appeared in the English language until Graham and Farquharson2reported four cases in 1931. Clinically the syndrome is characterized by premature senescence, generalized atrophy of all tissues, gradual failure of the body functions, mental torpor, apathy and death. The literature on the disease was reviewed to 1922 by Knoll,3and to 1930 by Werner Merz.4 ETIOLOGY The destruction of the anterior lobe of the hypophysis may be caused by a number of primary and secondary conditions, and a review of twenty-four selected cases with autopsy observations from the literature suggests the following principal factors in the order of their importance: puerperal sepsis (septic embolus), 9; syphilis,