Prolactin-Secreting Pituitary Adenomas in Women. IV. Pituitary Function in Amenorrhea Associated with Normal or Abnormal Serum Prolactin and Sellar Polytomography*
- 30 September 1980
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 51 (4), 830-835
- https://doi.org/10.1210/jcem-51-4-830
Abstract
An analysis of anterior pituitary function with respect to abnormal or normal serum prolactin (hPRL) concentrations (normal, < 20 ng/ml) and sellar polytomography was performed in 84 amenorrheic women to determine whether those with hyperprolactinemia and abnormal sellar polytomograms could be distinguished from amenorrheic patients without elevated hPRL levels or abnormal tomograms. These tests fail to differentiate hyperprolactinemia resulting from a pituitary tumor from that in which no tumor can be identified. A blunted hPRL response to TRH [thyroliberin] is characteristic of hyperprolactinemia in amenorrheic patients. While cyclic endogenous gonadotropin release is impaired in hyperprolactinemic, amenorrheic women, gonadotropin responses to GnRH [gonadotropin releasing hormone] are normal or augmented. These anterior pituitary function tests do not differentiate pituitary microadenomas from macroadenomas.This publication has 13 references indexed in Scilit:
- Detection, evaluation, and treatment of pituitary microadenomas in patients with galactorrhea and amenorrheaAmerican Journal of Obstetrics and Gynecology, 1977
- Functional Delineation of Hyperprolactinemic-Amenorrhea1Journal of Clinical Endocrinology & Metabolism, 1977
- Pituitary Autonomy in Hyperprolactinemic Secondary Amenorrhea: Results of Hypothalamic-Pituitary TestingJournal of Clinical Endocrinology & Metabolism, 1977
- Galactorrhea: A Study of 235 Cases, Including 48 with Pituitary TumorsNew England Journal of Medicine, 1977
- Diagnosis of prolactin-secreting pituitary microadenomaAmerican Journal of Obstetrics and Gynecology, 1976
- Pituitary Gonadotropin Response in Women with Idiopathic HyperprolactinemiaFertility and Sterility, 1976
- Hyperprolactinemic Anovulatory Syndrome*Journal of Clinical Endocrinology & Metabolism, 1976
- Utility of the Radioimmunoassay of Serum Thyrotrophin in ManAnnals of Internal Medicine, 1971
- A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasmaJournal of Clinical Pathology, 1962
- AN IMMUNOCHEMICAL ASSAY OF TOTAL EXTRACTABLE INSULIN IN MAN *JCI Insight, 1960