INHIBITION OF FUNCTIONAL AND MORPHOLOGICAL-DIFFERENTIATION OF CULTURED MOUSE MYELOID-LEUKEMIA CELLS BY TUMOR PROMOTERS
- 1 January 1979
- journal article
- research article
- Vol. 70 (1), 119-123
Abstract
Addition of a potent tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA), to mouse myeloid leukemia line cells (MI) in suspension cultures inhibited both functional and morphological differentiation of the cells induced by dexamethasone or protein inducer. A positive correlation was found between the tumor-promoting activities of several plant diterpenes and their inhibition of cell differentiation. The inhibition of cell differentiation by TPA was reversible and was unrelated to its cytotoxic action.This publication has 7 references indexed in Scilit:
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