Effect of periodontal treatment on the C‐reactive protein and proinflammatory cytokine levels in Japanese periodontitis patients
- 26 November 2004
- journal article
- Published by Wiley in Journal of Periodontal Research
- Vol. 40 (1), 53-58
- https://doi.org/10.1111/j.1600-0765.2004.00772.x
Abstract
Background: Recent epidemiological studies have shown that individuals with periodontitis have a significantly increased risk of developing coronary heart disease. In addition to conventional risk factors, chronic infection and subsequent production of systemic inflammatory markers may be associated with this increased risk. Objectives: The aim of the present study was to determine whether the presence of chronic periodontitis and subsequent periodontal treatment could influence the serum levels of C-reactive protein (CRP), interleukin-6 and tumor necrosis factor-α (TNF-α) in a Japanese population. Methods: Sera were obtained from 24 patients with moderate to advanced periodontitis at the baseline examination and at reassessment after completion of treatment. As a control, sera were also obtained from 21 subjects without periodontitis. High-sensitivity CRP (hs-CRP) was measured using nephelometry with a latex particle-enhanced immunoassay and interleukin-6 and TNF-α were determined by sensitive enzyme-linked immunosorbent assay. Results: The levels of hs-CRP and interleukin-6 in the sera of this Japanese population seemed to be much lower than those reported in other populations. TNF-α on the other hand, demonstrated similar levels between this Japanese and other populations. Periodontal status demonstrated a significant improvement in all patients following treatment. There was a trend toward higher hs-CRP levels in patients at baseline compared with control subjects. Hs-CRP level tended to decrease with improvement of the periodontal condition following treatment and approached that of control subjects, although this decline was not statistically significant. interleukin-6 and TNF-α levels did not change following periodontal treatment. Furthermore, there was no difference in the serum levels of these inflammatory cytokines between patients either at baseline or at reassessment and control subjects. Conclusions: In this pilot study, we were unable to show that periodontal disease significantly affects the serum levels of systemic inflammatory markers. However, this does not necessarily mean that periodontitis does not contribute to the total burden of inflammation as there was a tendency for hs-CRP to decrease following successful periodontal treatment. Large-scale studies are clearly needed to determine the impact of periodontal disease on systemic inflammation.Keywords
This publication has 34 references indexed in Scilit:
- Markers of Inflammation and Cardiovascular DiseaseCirculation, 2003
- Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial CellsCirculation, 2000
- Atherosclerosis — An Inflammatory DiseaseNew England Journal of Medicine, 1999
- Potential Pathogenic Mechanisms of Periodontitis‐Associated Pregnancy ComplicationsAnnals of Periodontology, 1998
- Periodontitis: A Risk Factor for Coronary Heart Disease?Annals of Periodontology, 1998
- The Pathobiology of Periodontal Diseases May Affect Systemic Diseases: Inversion of a ParadigmAnnals of Periodontology, 1998
- Periodontal Disease and Cardiovascular DiseaseThe Journal of Periodontology, 1996
- Dental Infection and the Risk of New Coronary Events: Prospective Study of Patients with Documented Coronary Artery DiseaseClinical Infectious Diseases, 1995
- Host Responses in Patients With Generalized Refractory PeriodontitisThe Journal of Periodontology, 1994
- Dental disease and risk of coronary heart disease and mortality.BMJ, 1993