The trial use of clozapine for abnormal involuntary movement disorders
- 1 March 1979
- journal article
- research article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 136 (3), 317-320
- https://doi.org/10.1176/ajp.136.3.317
Abstract
Patients (12) with abnormal involuntary movement disorders were treated with clozapine in a double-blind, placebo-controlled trial. The cohort consisted of individuals with Gilles de la Tourette''s syndrome, Huntingdon''s disease, and atypical persistent dyskinesia that was drug induced. Two subjects were dropped from the protocol due to complications. Two patients with Huntington''s disease showed a marked decrease in movements; other individuals obtained no significant therapeutic benefits. Seven of the 10 patients completing the trial experienced moderate or marked side effects.This publication has 8 references indexed in Scilit:
- Gilles de la Tourette's syndrome, tardive dyskinesia, and psychosis in an adolescentAmerican Journal of Psychiatry, 1978
- PHARMACOLOGICAL INVESTIGATIONS OF CHOLINERGIC IMBALANCE HYPOTHESES OF MOVEMENT-DISORDERS AND PSYCHOSIS1978
- Clozapine in tardive dyskinesiaPsychopharmacology, 1978
- Agranulocytosis during treatment with clozapineEuropean Journal of Clinical Pharmacology, 1977
- Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic DrugsScience, 1976
- Antischizophrenic drugs: Affinity for muscarinic cholinergic receptor sites in the brain predicts extrapyramidal effectsJournal of Psychiatric Research, 1974
- CLOZAPINE AND HALOPERIDOL IN A SINGLE‐BLIND CROSS‐OVER TRIAL: THERAPEUTIC AND BIOCHEMICAL ASPECTS IN THE TREATMENT OF SCHIZOPHRENIAActa Psychiatrica Scandinavica, 1974
- Treatment of Tourette's SyndromeArchives of General Psychiatry, 1973