Abstract
T helper (Th) cells producing interleukin (IL)-17, IL-22, and tumor necrosis factor (TNF) form the key T cell population driving psoriasis pathogenesis. A cellular source of IL-17A in the skin is the γδ T cell population. The majority of dermal γδ T cells express a T cell receptor containing Vγ4 together with the chemokine receptor CCR6. Consistent with the findings of {1,2}, this study found an increased number of γδ T cells, which produce large amounts of IL-17A, in the affected skin of patients with psoriasis. This Recommendation is of an article referenced in an F1000 Faculty Review also written by Franziska C. Eberle, Jürgen Brück, Julia Holstein, Kiyoshi Hirahara, and Kamran Ghoreschi.