Abstract
1. The hearts of Busycon canaliculatum and Strombus gigas were found to respond to applied neurohumors as do the myogenic hearts of other gastropods. Acetyicholine was cardio-inhibitory, and 5-hydroxytryptamine was cardio-acceleratory, in concentrations low enough to suggest that they might be the normal regulatory neurohumors. 2. The Busycon canaliculatum radula protractor was contracted by acetylcholine, and could then be relaxed rhythmically by 5-hydroxytryptamine, tryptamine, and adrenalin, all of which raise the tonus of the ventricle.