I have elected to present for consideration and discussion the results of some clinical and pathologic studies in acute renal infection. The subject is one which has interested me for several years, and at infrequent intervals and in a rather desultory manner I have followed out some experimental work, which at times has served only to confirm the work of others, and at other times has furnished a rational explanation of certain clinical phenomena observed in some of the severer forms of renal infection. The first series of experiments, which had to do with a determination of some of the more frequently encountered causes of acute hematogenous infections, has already been published. During the past year, however, some further experiments have been carried out with a view to determining the effects of some of the rarer etiologic factors, as the various degrees of anemia, passive hyperemia and aseptic infarcts, in