Convenient, One-Step Syntheses of 2-Fluoroveratrole And 2-Fluoroveratraldehyde
- 1 October 1986
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 16 (12), 1551-1556
- https://doi.org/10.1080/00397918608056408
Abstract
Metalated veratraldehyde and veratrole were quenched with perchloryl fluoride to provide one-step syntheses of 2-fluoroveratraldehyde and 2-fluoroveratrole, respectively. Previous syntheses of these precursors to 2-fluorodopamine and 5-fluoronorepinephrine are multi-step processess which involve introduction of fluorine at an early stage. Perchloryl fluoride is a potentially hazardous reagent, and should be used only on an appropriate (millimolar) scale with precautions.Keywords
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