A new immunoglobulin variant: gamma3 heavy chain disease protein CHI.
- 1 May 1976
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 73 (5), 1552-1555
- https://doi.org/10.1073/pnas.73.5.1552
Abstract
Protein CHI is a defective human .gamma.3 H chain immunoglobulin with a deletion encompassing a portion of the variable and constant regions. Joining of the 2 pieces takes place at the beginning of an extra fragment (Fh) in the constant region where repetitive sequences are found, apparently as the result of gene duplications and/or unequal crossover between .gamma. genes. A 45 nucleotide fragment is probably the repetitive unit coding for the extra fragment.This publication has 26 references indexed in Scilit:
- The Amino Acid Sequence of a Major Nonimmunoglobulin Component of Some Amyloid FibrilsJournal of Clinical Investigation, 1972
- Pathways through Networks of Branched DNAScience, 1970
- The Reliability of Molecular Weight Determinations by Dodecyl Sulfate-Polyacrylamide Gel ElectrophoresisJournal of Biological Chemistry, 1969
- The gel-filtration behaviour of proteins related to their molecular weights over a wide rangeBiochemical Journal, 1965
- Clinical and immunochemical studies of four cases of heavy (Hγ2) chain diseaseThe American Journal of Medicine, 1964
- Heavy chain disease—A new disorder of serum γ-globulinsThe American Journal of Medicine, 1964
- Equilibrium Ultracentrifugation of Dilute Solutions*Biochemistry, 1964
- Peptide Separation by Two-dimensional Chromatography and ElectrophoresisJournal of Biological Chemistry, 1959
- Zone ElectrophoresisPublished by Wiley ,1954
- ANTIGEN - ANTIBODY REACTIONS IN GELS .4. TYPES OF REACTIONS IN COORDINATED SYSTEMS OF DIFFUSION1953