A new immunoglobulin variant: gamma3 heavy chain disease protein CHI.
- 1 May 1976
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 73 (5), 1552-1555
- https://doi.org/10.1073/pnas.73.5.1552
Abstract
Protein CHI is a defective human .gamma.3 H chain immunoglobulin with a deletion encompassing a portion of the variable and constant regions. Joining of the 2 pieces takes place at the beginning of an extra fragment (Fh) in the constant region where repetitive sequences are found, apparently as the result of gene duplications and/or unequal crossover between .gamma. genes. A 45 nucleotide fragment is probably the repetitive unit coding for the extra fragment.This publication has 26 references indexed in Scilit:
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