THE PHENOMENON OF LOCAL SKIN REACTIVITY TO BACTERIAL FILTRATES: ELICITATION OF LOCAL REACTIVITY BY WAY OF THE VASCULAR SYSTEM

Abstract

The skin of the rabbit''s ear is considerably more resistant than the abdominal skin to the phenomenon of local skin reactivity to bacterial filtrates. 10 times the provocative dose is required if it is given into the vein of the prepared ear and 30 times the provocative dose if it is given into the vein of the non-prepared ear. The state of reactivity cannot be elicited by a preparatory intra-ven. inj. of bacterial filtrates alone into clamped and non-clamped ears. The state also fails to appear in combination with cold, xylol, ethyl urethane, pilocarpine hydrochloride, atropine, Ca gluconate, guinea pig liver extract, histamine dihydrochloride, adrenalin Cl, and pituitrin. Preparatory intraven. injs. of toxins are capable of eliciting the state of reactivity in the rabbit''s ear when they are accompanied by thermal hyperemia (i.e., exposure to 45[degree], 50[degree], and 55[degree]C). It is also possible to induce the state of reactivity when a mixture of the preparatory factors with testicular extract is given into the veins of clamped ears. The incubation period required may be less than 2 hrs. Various observations are discussed concerning the elicitation of the phenomena of organ reactivity by means of live bacterial cultures and the filtrates thereof.