Nichtenzymatische Transaminierung einiger schwefelhaltiger Aminosäure-Analoga mit Glyoxylsäure und Metallionen

Publisher Website
Google Scholar
Abstract
The effect of y -substitution of amino acids on the rate of their Cu(n)-dependent, nonenzymatic transamination with glyoxylic acid was studied. With the 7-substituents, methylene, thioether, sulfoxide, sulfone, the rate of transamination increases in that order. The result of electronegative substitution is attributed to an increased lability of the a-hydrogen of the amino acid, which favors a prototropic rearrangement within the Cu complex of the Schiff''s base of amino acid and glyoxylic acid.