Iproveratril: A Nonspecific Antagonist of Peripheral Vascular Reactivity

Abstract

The effect of iproveratril (α-isopropyl- α-[(N-methyl-N-homoveratryl)-γ-aminopropyl]-3,4-dimethoxyphenolacetonitrile hydrochloride) on peripheral vascular responses to isoproterenol (ISO), norepinephrine (NE), angiotensin II (A), and nitroglycerin (GTN) was evaluated in the canine hindlimb and hindpaw preparations perfused with autologous blood at constant flow. Iproveratril (30–300 μg/kg intravenous) dilated the hindlimb and hindpaw perfused at constant flow. Responses to intra-arterial ISO, NE, and A were significantly reduced when evaluated 10 min after iproveratril. Iproveratril did not alter the vasodilator responses to GTN. These results show that iproveratril depresses the vascular responses of the hindlimb and hindpaw to stimulants of α and β adrenergic and angiotensin receptors and justify the conclusion that iproveratril is not a selective antagonist of peripheral β-receptors.