RELATIONSHIP OF LEUKOCYTE ELASTASE CONCENTRATION TO SEVERITY OF EMPHYSEMA IN HOMOZYGOUS ALPHA-1-ANTITRYPSIN-DEFICIENT PERSONS
- 1 January 1977
- journal article
- research article
- Published by Elsevier
- Vol. 115 (5), 793-803
- https://doi.org/10.1164/arrd.1977.115.5.793
Abstract
In 9 .alpha.1-antitrypsin-deficient (PiZZ) persons 40-53 yr of age, the relationships between the concentration of elastolytic protease of polymorphonuclear leukocyte granules and cigarette smoking, and the degree of abnormality in detailed pulmonary function tests were explored. Regardless of the statistical analytic approach used, elastase concentration was related more frequently and significantly than smoking history to the degree of abnormality observed in tests of pulmonary function. The severity of pulmonary dysfunction in PiZZ persons apparently may be determined by variables other than age and cigarette smoking, including the concentration of elastolytic protease in leukocyte lysosomes.This publication has 8 references indexed in Scilit:
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