Combined effect of ascorbic acid deficiency and underfeeding on the hepatic carnitine level in guinea-pigs

Abstract

Summary Liver carnitine level decreased from 249±16.1 nmoles/g (mean ±SEM) control value to 148±9.8 nmoles/g (59.4%) in ascorbic acid deficient guinea-pigs, while in the underfed (‘pair-fed’) group it decreased to 181±14.1 nmoles/g (72.6%). Underfeeding also resulted in lower ascorbic acid levels; the depression of carnitine in the underfed animals could be prevented by an overdose (200 mg daily) of ascorbic acid.