Note on the alleged reversal of the denaturation of serum-albumin

Abstract

Confirmatory evidence for the possibility of reversing the heat-denaturation of serum-albumin was not found. Serum-albumin may be heated in certain acid solns. without being appreciably denatured. It is suggested that, in some exps. apparently demonstrating reversal of denaturation, the albumin recovered had not been denatured at all but had been enclosed by precipitated granules and thus protected by a "skin" of denatured protein.