DIRECT EVIDENCE FOR NUCLEAR SYNTHESIS OF CYTOPLASMIC RIBOSE NUCLEIC ACID
- 15 November 1955
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 41 (11), 874-880
- https://doi.org/10.1073/pnas.41.11.874
Abstract
A more direct experimental design than has heretofore been employed was developed to test the hypothesis of nuclear synthesis of ribonucleic acid (RNA) and its transfer to the cytoplasm. The RNA of the nucleus was labeled with radioactive tracer, and the nucleus grafted into a cell with unlabeled RNA. Transmission of labeled material from nucleus to cytoplasm was then traced directly by auto-radiography. The evidence presented shows that RNA is synthesized in the nucleus and that RNA, or at least a nucleus-modified precursor of RNA, is transmitted to the cytoplasm.Keywords
This publication has 8 references indexed in Scilit:
- Action of Ribonuclease and Ribonucleic Acid on Living AmœbæNature, 1955
- The assimilation of amino acids by bacteria. 20. The incorporation of labelled amino acids by disrupted staphylococcal cellsBiochemical Journal, 1955
- The assimilation of amino acids by bacteria. 21. The effect of nucleic acids on the development of certain enzymic activities in disrupted staphylococcal cellsBiochemical Journal, 1955
- Promotion of Incorporation of Amino-acids by Specific Di- and Tri-nucleotidesNature, 1955
- The role of the nucleus in protein synthesis in AmoebaBiochimica et Biophysica Acta, 1954
- The role of the nucleus in the maintenance of ribonucleic acid in Amoeba proteusBiochimica et Biophysica Acta, 1954
- Nucleic Acid Template HypothesesNature, 1953
- A TIME STUDY OF THE INCORPORATION OF RADIOPHOSPHORUS INTO THE NUCLEIC ACIDS AND OTHER COMPOUNDS OF A TRANSPLANTED MOUSE MAMMARY CARCINOMA1953