Serum Beta-Lipoprotein Subfractions in Polyacrylamide Gel Electrophoresis Associated with Coronary Heart Disease

Abstract

Subfractions of β-lipoprotein occurred more frequently in serum from patients with coronary heart disease than in serum from patients with no sign of coronary heart disease. Two β-lipoprotein subfractions were observed in polyacrylamide gel electrophoresis. The sera containing a β-lipoprotein sub-fraction with a position close to the β-lipoprotein band showed Lp(a) antigenic properties. Triglycerides were raised in the sera with β-lipoprotein subfractions. The cholesterol level was significantly higher in the coronary heart disease group but was not correlated to the presence of the β-lipoprotein subfraction. The β-lipoprotein subfraction may possibly represent an additional risk factor in the genesis of coronary heart disease, even in the absence of other hyperlipoproteinemias.