.beta.-Adrenergic blocking agents. 19. 1-Phenyl-2-[[(substituted-amido)alkyl]amino]ethanols
- 31 January 1980
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 23 (2), 112-117
- https://doi.org/10.1021/jm00176a002
Abstract
The synthesis of a series of derivatives of 1-phenyl-2-[[(substituted amido)alkyl]amino]ethanols is described. The compounds were studied for .beta.-adrenoceptor blocking properties, and many showed a surprising degree of potency and .beta.1-cardioselectivity when tested in vivo in anesthetized cats. The structure-activity relationships shown by this series of compounds are discussed and related to known .beta.-adrenergic blocking agents.This publication has 3 references indexed in Scilit:
- 2-Methoxyphenylethanolamines, potential .beta.-adrenergic blocking agentsJournal of Medicinal Chemistry, 1978
- .beta.-Adrenergic blocking agents. 18. 1-(Aryloxy)-3-(arylthioalkylamino)propan-2-ols and 1-substituted alkylthioamino-3-(aryloxy)propan-2-olsJournal of Medicinal Chemistry, 1978
- .beta.-Adrenergic blocking agents. 17. 1-Phenoxy-3-phenoxyalkylamino-2-propanols and 1-alkoxyalkylamino-3-phenoxy-2-propanolsJournal of Medicinal Chemistry, 1977