The Time-Concentration Curve of Local Anesthetics.

Abstract

A method is described to determine the minimum concn. for anesthesia (Cm) of the motor fibers of the frog sciatic nerve. Applying the theory of heat conduction in an infinitely long cylinder, C could be expressed as a function of Cm, T, D (diffusion constant of the anesthetics) and R (nerve radius). The data obtained conform with the theory.