EFFECT OF METHIONINE, NORLEUCINE, AND LYSINE DERIVATIVES ON CEPHALOSPORIN C FORMATION IN CHEMICALLY DEFINED MEDIA
- 1 February 1963
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 85 (2), 339-+
- https://doi.org/10.1128/jb.85.2.339-344.1963
Abstract
In chemically defined media for production of cephalosporin-C by Cephalosporium sp. the requirement for methionine can be satisfied by norleucine. Further stimulation of antibiotic production was obtained with the lysine derivatives [epsilon] -N-acetyl-L-lysine and [epsilon]-amino-caproic acid but not with lysine itself. Also inactive were a-aminoadipic and ketoadipic acids. Other lysine derivatives were found to inhibit cephalosporin-C production at 0.01 [image]. The final medium supported the production of approximately 0.5 g of cephalosporin-C per liter of medium.Keywords
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