MINERALOCORTICOID REPLACEMENT IN ADDISON'S DISEASE
- 1 May 1979
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 10 (5), 499-506
- https://doi.org/10.1111/j.1365-2265.1979.tb02107.x
Abstract
Eight patients with treated Addison''s disease were studied receiving different doses of fludrocortisone together with a constant intake of glucocorticoid. Plasma renin activity (PRA), blood pressure, pulse rate and plasma K and urea concentrations were measured after 2 wk periods on each dose. In 2 patients, PRA measurements indicated that mineralocorticoid replacement therapy was inadequate. In 4 others, PRA remained normal throughout the study, even after fludrocortisone had been discontinued, suggesting that the drug was unnecessary for the maintenance of normal Na balance in these patients. Asymptomatic fludrocortisone overdosage was indicated by a low plasma K concentration, but not by PRA measurements which failed in this study to distinguish between adequate and excessive mineralocorticoid replacement.This publication has 9 references indexed in Scilit:
- Spironolactone-induced inhibition of aldosterone biosynthesis in primary aldosteronism: Morphological and functional studiesMetabolism, 1977
- Searching out low renin patients: Limitations of some commonly used methodsThe American Journal of Medicine, 1973
- The renin system: Variations in man measured by radioimmunoassay or bioassayKidney International, 1972
- Effect of Methyldopa on Plasma Renin Activity in ManCirculation Research, 1969
- Effect of Corticotropin on Aldosterone Excretion and Plasma Renin in Normal Subjects, in Essential Hypertension and in Primary AldosteronismJournal of Clinical Endocrinology & Metabolism, 1968
- RENIN ANGIOTENSIN CORTICOSTEROIDS AND ELECTROLYTE BALANCE IN ADDISONS DISEASE1968
- Normokalemic Primary AldosteronismJAMA, 1965
- Suppression of Plasma Renin Activity in Primary AldosteronismJAMA, 1964
- INFLUENCE OF SODIUM LOADING AND SODIUM DEPLETION ON PLASMA-RENIN IN MANThe Lancet, 1963