Effect of Age and Weight on Plasma Glucose and Insulin Responses in the Rat†
- 1 July 1977
- journal article
- research article
- Published by Wiley in Journal of the American Geriatrics Society
- Vol. 25 (7), 299-302
- https://doi.org/10.1111/j.1532-5415.1977.tb00641.x
Abstract
Plasma glucose and insulin responses to orally administered glucose were determined in rats of varying ages and weights. Glucose tolerance tends to deteriorate as rats grow from 1 mo. to 9 mo. of age. This change in glucose tolerance was associated with an increase in the response of plasma insulin to glucose, consistent with the hypothesis that the decline in glucose tolerance is due to a loss of normal insulin sensitivity. The changes in glucose and insulin responses could not be explained entirely on the basis of the associated weight gain. They seemed to be at least partially secondary to either age or an age-related factor other than obesity.This publication has 8 references indexed in Scilit:
- Effects of Age and Obesity on Insulin Binding to Isolated Adipocytes1212Endocrinology, 1975
- The effects of acute and chronic dexamethasone administration on insulin binding to isolated rat hepatocytes and adipocytesMetabolism, 1975
- Peptide hormone binding to receptors: A review of direct studies in vitroMetabolism, 1973
- The effects of age, feeding pattern and sucrose on glucose tolerance, and plasma free fatty acids and insulin concentrations in the ratBritish Journal of Nutrition, 1972
- Evidence that Glucose Load Is an Important Determinant of Plasma Insulin Response in Normal SubjectsDiabetes, 1971
- Use of Polyethylene Glycol to Separate Free and Antibody-Bound Peptide Hormones in Radioimmunoassays†Journal of Clinical Endocrinology & Metabolism, 1971
- Oral Glucose Tolerance During the Life-span of a Colony of RatsJournal of Gerontology, 1968