Interaction of CDP-choline with synaptosomal transport of biogenic amines and their precursors in vitro and in vivo in the rat corpus striatum
- 1 September 1978
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 34 (9), 1197-1199
- https://doi.org/10.1007/bf01922955
Abstract
Added to a striatal synaptosomal homogenate of rat brain, CDP-choline 10−4 M inhibits the uptake of norepinephrine (NE), dopamine (DA) and serotonin (5 HT) in a competitive fashion and enhances the uptake of tyrosine and tryptophan; administered to animals, CDP-choline (50 mg/kg/l h/i.v.) inhibits only the in vitro uptake of DA but enhances the uptake of precursors.Keywords
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