FURTHER STUDIES ON THE INHIBITION OF MONOAMINE SYNTHESIS BY MONOFLUOROMETHYLDOPA
Open Access
- 1 December 1980
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 70 (4), 571-576
- https://doi.org/10.1111/j.1476-5381.1980.tb09776.x
Abstract
1 α-Monofluoromethyldopa (MFMD, RMI 71963), a potent and selective enzyme-activated irreversible inhibitor of aromatic l-amino acid decarboxylase produces a substantial and long-lasting decrease in the catecholamine content of mouse brain, heart and kidney. 2 Single doses of MFMD reduce the 5-hydroxytryptamine concentration of mouse brain without altering the tryptophan concentration. 3 In animals treated with MFMD, peripheral but not brain noradrenaline is restored within 1 h to control levels by an intraperitoneal injection of dopamine.Keywords
This publication has 11 references indexed in Scilit:
- Monamine-depleting properties of a new and very potent enzyme-activated irreversible inhibitor of aromatic aminoacid decarboxylase: alpha-monofluoromethyldopa [proceedings].1979
- Determination of DOPA, dopamine, DOPAC, epinephrine, norepinephrine, α-monofluoromethyldopa and α-difluoromethyldopa in various tissues of mice and rats using reversed-phase ion-pair liquid chromatography with electrochemical detectionJournal of Chromatography B: Biomedical Sciences and Applications, 1979
- Inhibition of monoamine synthesis by irreversible blockade of aromatic aminoacid decarboxylase with α-monofluoromethyldopaLife Sciences, 1979
- α‐DIFLUOROMETHYL DOPA, A NEW ENZYME‐ACTIVATED IRREVERSIBLE INHIBITOR OF AROMATIC L‐AMINO ACID DECARBOXYLASEJournal of Neurochemistry, 1978
- Selective inhibitors of biosynthesis of aminergic neurotransmittersNature, 1978
- Decarboxylase inhibitorsPharmacology & Therapeutics. Part B: General and Systematic Pharmacology, 1975
- Transynaptic Regulation of Neuronal Enzyme SynthesisPublished by Springer Nature ,1975
- 5-Hydroxytryptamine and Other Indoles in the Central Nervous SystemPublished by Springer Nature ,1975
- Enzymes Involved in the Biosynthesis and Degradation of CatecholaminesPublished by Springer Nature ,1975
- ELUCIDATION OF RATE-LIMITING STEP IN NOREPINEPHRINE BIOSYNTHESIS IN PERFUSED GUINEA-PIG HEART1965