The drug release characteristics of various rectal suppositories as determined by specific ion electrodes
- 1 July 1971
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 23 (7), 490-494
- https://doi.org/10.1111/j.2042-7158.1971.tb08695.x
Abstract
Suppositories containing sodium phenobarbitone (200 mg) were manufactured with the following bases; cocoa butter, cocoa butter plus beeswax, Dehydag and polyethylene glycols. The release of sodium ions through a dialysis membrane was conveniently measured with a sodium-specific ion electrode. The method facilitates evaluation and comparison of suppository bases and allows continuous monitoring of the release of active ingredient.Keywords
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