ENHANCEMENT OF NADPH-DEPENDENT LIPID PEROXIDATION ACTIVITY BY ETHYLENE-DIAMINETETRAACETIC ACID (EDTA) IN THE PRESENCE OF FERROUS ION IN RABBIT LIVER MICROSOMES
Open Access
- 1 January 1977
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 27 (5), 653-657
- https://doi.org/10.1254/jjp.27.653
Abstract
The addition of EDTA to the incubation mixture containing rabbit liver microsomes and Fe2+ resulted in 2-fold increase of lipid peroxidation activity. Such an enhancement was not observed in rat liver microsomes. The maximum lipid peroxidation activity seen in rabbit microsomes in the presence of EDTA and Fe2+ was about 80% that seen in rat liver microsomes. Low lipid peroxidation activity in rabbit liver microsomes may account for the insufficiency of an EDTA-like factor(s) in rabbit liver microsomes. [Unsaturated fatty acids in liver microsomes undergo peroxidative degradation. This lipid peroxidation reaction is generally accepted as the cause of hepato-toxicity with ingestion of certain chemical compounds.].This publication has 9 references indexed in Scilit:
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