The corallopyronins, new inhibitors of bacterial RNA synthesis from Myxobacteria.
- 1 January 1985
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 38 (2), 145-152
- https://doi.org/10.7164/antibiotics.38.145
Abstract
From the culture broth of the myxobacterium, Corallococcus (Myxococcus) coralloides, 3 new antibiotics were isolated: corallopyronin A, B and C. The compounds, which are chemically related to the recently discovered myxopyronins, act mainly on gram-positive bacteria, with MIC [minimal inhibitory concentration] values between 0.1-10 .mu.g/ml, and only exceptionally or at much higher concentrations (MIC values; 100 and more .mu.g/ml) on gram-negatives. They do not inhibit eukaryotic organisms and show no toxicity for mice. The corallopyronins appear to block specifically eubacterial RNA polymerase.This publication has 2 references indexed in Scilit:
- Stigmatellin, a new antibiotic from Stigmatella aurantiaca (Myxobacterales). I. Production, physico-chemical and biological properties.The Journal of Antibiotics, 1984
- The myxopyronins, new inhibitors of bacterial RNA synthesis from Myxococcus fulvus (Myxobacterales).The Journal of Antibiotics, 1983