Pyoderma Gangrenosum
- 1 June 1978
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 114 (6), 906-911
- https://doi.org/10.1001/archderm.1978.01640180040010
Abstract
• A 34-year-old man with chronic active hepatitis and pyoderma gangrenosum demonstrated abnormalities in neutrophil and monocyte function. Monocytes from this man had diminished chemotaxis and bacterial phagocytosis. These functions were significantly improved in vitro after one hour of incubation of monocytes with 105 hydrocortisone. Neutrophil function was normal for bactericidal activity and phagocytosis, but neutrophil chemotaxis was diminished. A plasma inhibitor was not found to explain these phagocyte alterations. (Arch Dermatol 114:906-911, 1978)Keywords
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