Quantification of resting myocardial blood flow in a pig model of acute ischemia based on first‐pass MRI
- 20 April 2005
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 53 (5), 1223-1227
- https://doi.org/10.1002/mrm.20457
Abstract
Qualitative and semiquantitative contrast‐enhanced (CE) dynamic perfusion MRI techniques are established as noninvasive diagnostic means of assessing coronary artery disease. However, to date quantification of myocardial blood flow (MBF) has not reached the same acceptance as MBF quantification with nuclear techniques. To validate quantification of MBF at rest using the extracellular contrast agent (CA) Gd‐DTPA, we performed an animal study in a pig model of acute myocardial ischemia. We quantified MBF from MRI data with a mathematical model (MMID4) of the underlying vasculature. These MBF results were subsequently compared with the results from fluorescent microspheres. The study showed a correlation of r = 0.66 between MBF estimates obtained with MRI and those obtained with fluorescent microspheres. The correlation for ischemic and nonischemic myocardium was r = 0.86 and r = 0.47, respectively. In conclusion, quantification of resting MBF using MMID4 is a valid method under conditions of acute myocardial ischemia. Magn Reson Med 53:1223–1227, 2005.Keywords
This publication has 17 references indexed in Scilit:
- Application of C1-Esterase Inhibitor During Reperfusion of Ischemic MyocardiumCirculation, 2001
- Direct comparison of an intravascular and an extracellular contrast agent for quantification of myocardial perfusionThe International Journal of Cardiovascular Imaging, 1999
- Magnetic resonance quantification of the myocardial perfusion reserve with a Fermi function model for constrained deconvolutionMedical Physics, 1998
- MRI quantitative myocardial perfusion with compartmental analysis: A rest and stress studyMagnetic Resonance in Medicine, 1997
- Myocardial perfusion reserve: assessment with multisection, quantitative, first-pass MR imaging.Radiology, 1997
- MR first pass imaging: quantitative assessment of transmural perfusion and collateral flowThe International Journal of Cardiovascular Imaging, 1997
- Myocardial perfusion and function in dogs with moderate coronary stenosisMagnetic Resonance in Medicine, 1996
- Myocardial perfusion modeling using MRIMagnetic Resonance in Medicine, 1996
- Voltage-dependent potentiation of neuronal L-type calcium channels due to state-dependent phosphorylationAmerican Journal of Physiology-Cell Physiology, 1995
- Regional myocardial blood volume and flow: First‐pass MR imaging with polylysine‐Gd‐DTPAJournal of Magnetic Resonance Imaging, 1995