Potentiation of host-mediated antitumor activity in mice by .BETA.-glucan obtained from Grifola frondosa (maitake)
- 1 January 1987
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 35 (1), 262-270
- https://doi.org/10.1248/cpb.35.262
Abstract
A polysaccharide (3-branched .beta.-1.6-glucan MT-2) extracted from fruit bodies of Grifola frondosa (Maitake) showed an antitumor effect against mouse syngeneic tumors (MM-46 carcinoma and IMC-carcinoma). It is not only directly activates various effector cells (macrophages, natural killer cells, killer T cells, etc.) to attack tumor cells, but also potentiates the activities of various mediators including lymphokines and interleukin-1. Thus, it acts to potentiate cellular functions and at the same time to prevent a decrease of immune functions of the tumor-bearing host.This publication has 9 references indexed in Scilit:
- Effect of a polysaccharide fraction from Grifola frondosa on immune response in mice.Journal of Pharmacobio-Dynamics, 1985
- AUGMENTATION OF NATURAL-KILLER CELL-ACTIVITY BY LIPOPOLYSACCHARIDE THROUGH SEPARABLE EFFECTS ON THE BINDING OF NONADHERENT LYMPHOCYTES TO TUMOR TARGETS AND TUMOR KILLING1984
- IMMUNOPOTENTIATION BY A NEW ANTITUMOR POLYSACCHARIDE, DMG, A DEGRADED D-MANNO-D-GLUCAN FROM MICROELLOBOSPORIA-GRISEA CULTURE FLUID1984
- SPECIFIC ADOPTIVE IMMUNOTHERAPY WITH TUMOR-SPECIFIC CYTO-TOXIC T-LYMPHOCYTE CLONE FOR MURINE MALIGNANT GLIOMAS1984
- ELIMINATION OF TUMOR-ENHANCING CELLS BY CYCLOPHOSPHAMIDE AND ITS RELEVANCE TO CYCLOPHOSPHAMIDE THERAPY OF A MURINE MAMMARY-TUMOR1981
- β (1–3) Glucans as a probe for T cell specific immune adjuvantsCellular Immunology, 1978
- BETA(1-]3) GLUCAN-MEDIATED AUGMENTATION OF ALLOREACTIVE MURINE CYTOTOXIC LYMPHOCYTES-T INVIVO1978
- Bidirectional Amplification of Macrophage-Lymphocyte Interactions: Enhanced Lymphocyte Activation Factor Production by Activated Adherent Mouse Peritoneal CellsThe Journal of Immunology, 1977
- The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes.Journal of Clinical Investigation, 1975