Studies and perspectives of signal transduction in the skin
- 1 November 1992
- journal article
- review article
- Published by Wiley in Experimental Dermatology
- Vol. 1 (5), 207-220
- https://doi.org/10.1111/j.1600-0625.1992.tb00079.x
Abstract
Tumor-promoting phorbol ester and epidermal growth factor (EGF) exert marked influences on the proliferation and differentiation of keratinocytes. These two agents bring their physiological functions into play via protein kinase C (PKC) activation (and/or down regulation) and protein tyrosine kinase, respectively. In this paper, the present situation in the studies on the signal transduction of keratinocytes centering around these two kinases is discussed. An outline of studies on signal transduction of cells other than keratinocytes in the skin is also given.Keywords
This publication has 121 references indexed in Scilit:
- Protein kinases and protooncogenes: biochemical regulators of the eukaryotic cell cycleBiochemistry, 1991
- Regulation of creatine phosphokinase B activity by protein kinase CBiochemical and Biophysical Research Communications, 1990
- Cyclic adenosine monophosphate levels and the function of skin microvascular endothelial cellsJournal of Cellular Physiology, 1990
- Tissue distribution of smg p25A, a ras p21-like GTP-binding protein, studied by use of a specific monoclonal antibodyBiochemical and Biophysical Research Communications, 1989
- Diacylglycerols, unlike phorbol esters, do not induce homologous desensitization or down-regulation of protein kinase C in Swiss 3T3 cellsBiochemical and Biophysical Research Communications, 1989
- Calcium-induced assembly of adherens junctions in keratinocytes.The Journal of cell biology, 1987
- A novel type of phorbol ester-dependent protein phosphorylation in the particulate fraction of mouse epidermisBiochemical and Biophysical Research Communications, 1986
- Phorbol diesters promote β-adrenergic receptor phosphorylation and adenylate cyclase desensitization in duck erythrocytesBiochemical and Biophysical Research Communications, 1984
- Phorbol ester tumor promoters induce epidermal transglutaminase activityBiochemical and Biophysical Research Communications, 1980
- Early prostaglandin E synthesis is an obligatory event in the induction of cell proliferation in mouse epidermis in vivo by the phorbol ester TPABiochemical and Biophysical Research Communications, 1980